Author Topic: Flurbiprofen For Bone Growth  (Read 431 times)

berkeley07

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Flurbiprofen For Bone Growth
« on: January 05, 2017, 04:09:29 pm »
Flurbiprofen enhances growth and cancellous and cortical bone accumulation in rapidly growing long bones. - PubMed - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/?term=2660884

There was a decrease in osteoclast numbers (-62 to -70%), an insignificant decrease in osteoblast numbers (-5 to -30%) per mm of bone surface and a decrease in osteoclast to osteoblast ratio (-35 to -56%). The findings presented are compatible with the conclusion that flurbiprofen, induced changes in rapidly growing long bones by reducing osteoclast activity and recruitment, stimulating longitudinal and radial growth, increasing the cortical bone mass by stimulated periosteal bone growth and depressed endosteal resorption, and increasing cancellous bone mass by depressed trabecular bone resorption without affecting bone formation.

Flurbiprofen-induced stimulation of periosteal bone formation and inhibition of bone resorption in older rats. - PubMed - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/3248202

There was an insignificant increase in metaphyseal cancellous bone mass. The current study leads to the conclusion that flurbiprofen-stimulated periosteal bone growth was due to direct stimulation of osteoblast recruitment and activity independent of longitudinal bone growth. Further, it confirms early findings in young rats that flurbiprofen induced depressed bone resorption without lowering bone formation. However, because of insufficient treatment time, the older rat did not accumulate bone as the young rats did.

The later study is promising as it shows rapid bone growth even for mature rats with closed growth plates, although not to the same extent as the younger rats. If this were to be ran with an aromatase inhibitor and growth hormone, would it lead to more masculine characteristics and increased height - especially in teens with open growth plates (the aromatase inhibitor would prevent them from closing)?

I am considering this in combination with increasing my testosterone levels through hormones, diet, and exercise, and also supplementing with calcium, vitamin K2 MK-4, and D3.

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Betterbytheday

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Re: Flurbiprofen For Bone Growth
« Reply #1 on: January 06, 2017, 07:20:05 am »
Came across that before when researching on bone growth. Not too sure what to make of it cause there is not much evidence with exception to those studies. Very interesting though. I just wish there's more studies and people testing it out.

Should maybe take it to the height growth forums. Some short dudes are willing to try and take anything to increase height and they would know everything to take if it helped in some way because they research extremely and would try every supplement/meds under the sun before investing in expensive Leg lengthening surgery. that was where I heard about the estrogen growth plates thing.

Ryan

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Re: Flurbiprofen For Bone Growth
« Reply #2 on: January 10, 2017, 04:44:53 pm »
Speaking about height growth? Is that possible..and how does it work? Conventionalism says that only these limb lengetning works, while ive read somewhere on another source you can take some cocktail to increase your height. Like grow taller for dummies book? or is that in your ipinion a scam? I really do not know much about growing taller in height!